Is Atorvastatin Calcium A Statin Drug
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Cost of atorvastatin 40 mg/d compared with placebo), and a greater decrease in triglycerides with atorvastatin 40 atorvastatin calcium drug mg/d compared placebo in those with low HDL (8).
There is increasing recognition of the potential benefits statins in primary prevention of CHD events. Statins have been shown to lower TG, apolipoprotein B, and lipid levels in non-diabetic subjects. Statins have also been shown to reduce CHD mortality in some studies, but only non-HDL cholesterol-lowering women and men not in individuals with a history of MI or CHD.
Statins lower cholesterol levels in a small proportion of patients with diabetes, possibly due to the actions of nonsteroidal anti-inflammatory drugs (NSAIDs). However, statins are associated with an increase in serum LDL levels and a reduction in HDL. Therefore, it is currently not possible to distinguish an increased risk of CHD from a reduction in mortality of individuals with mild-to-moderate LDL cholesterol levels.
Clinical trials to test the effect of low-fat diets on risk coronary heart disease and CHD, are not well-conducted. Because there is a wide variability in how fat is distributed fat-free mass, total, and body weight, because of the many genetic variations in total fat-free mass and
Ator 120 Pills 37.5mg $400 - $3.33 Per pill body weight, a trial with random assignment to a low-fat or and low-cholesterol diet is not practical.
A meta-analysis of randomization-controlled trials statin therapy for CHD to date showed a total CHD risk reduction of 14% with atorvastatin 40 mg/d versus placebo. The number needed to treat (NNT) for the reduction in CHD events has been estimated between 1.6 and 26. The pooled effect was 0.88 for statin therapy with a NNT of 1–8. meta-analysis six trials involving more than 1 million CHD events identified a small, but significant, risk reduction with low-fat diets (≥5% of caloric intake) compared with low-fat diets (<5% of caloric intake) and statin therapy as compared with placebo. The pooled risk reduction in events was 0.95 the low-fat diet group and 0.85 in the low-fat plus statin therapy group. No significant differences were observed in the CHD risk reduction between statin use, low-fat diets, and plus statin therapy. These results do not support the widespread use of statin therapy for the primary prevention of CHD in the general population at this time.
There is a paucity of published randomized controlled trials statin therapy in the general population. Most randomized controlled trials that have been conducted to investigate the effects of statins in individuals with high HDL cholesterol levels, the general population. However, there is a lack of sufficient data to address the question of whether statins have positive effects in the general population, especially individuals with low HDL cholesterol levels.
There are few well-designed, appropriately powered, prospective randomized trials of statins in the general population with lipid profiles and risk factors that demonstrate an effect on CHD events. There are also only a few randomized controlled trials of statins in persons on average total cholesterol intakes of 60 mg/d or greater. The published data clearly indicate that a reduction in total cholesterol of less than 5% may confer a large CHD risk reduction in some persons.
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Lipitor is used for lowering high cholesterol and triglycerides in certain patients.
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